Endocrine Abstracts

Introduction: Poorly-controlled hypothyroidism is frequently associated with sleep disorders such as impaired sleep quality and obstructive sleep apnea. The aim of this study was to evaluate the sleep quality in patients with well-controlled primary hypothyroidism.Methods: This was a single-center, cross-sectional study including 50 patients with well-controlled primary hypothyroidism (TSH level within the normal range: 0.35-4.94 mIU/l) for at least one ...

Introduction: Von Hippel-Lindau (VHL) disease is an autosomal dominant inherited syndrome predisposing to a variety of highly vascularised tumors in different organs. Although bilateral pheochromocytoma was reported in patient with VHL disease, the coexistence of primary hyperparathyroidism is not a common condition. Herein we report a case of a primary hyperparathyroidism secondary to an ectopic secretion of intact parathyroid hormone (PTH) in a patient with VHL disease and b...

Introduction: Osteogenesis imperfecta also known as Lobstein’s disease (LD) is a rare disorder of type 1 collagen characterized by an increased susceptibility to bone fractures. Its coexistencewith primary hyperparathyroidism (PHP) was rarely described. Herein we report a new case of a primary hyperparathyroidismin a patient with a history of Lobstein’s disease.Observation: A 35-year-old woman was referred to our departmentfor hypercalcemia. He...

Background: Thyroid nodules are the most common thyroid disease. In the majority of cases, they are benign. However, 5 to 15% of nodules are cancer. The aim of our study was to determine the clinical and biological predictive factors of malignancy in thyroid nodules.Methods: We performed a retrospective descriptive study including 100 patients collected in the endocrinology department of La Rabta hospital over 18 year old period (2000–2018). All the...

Background: Ultrasound is valuable for identifying many malignant or potentially malignant thyroid nodules. The aim of this study was to evaluate the efficacy of ultrasonographic (US) features in predicting the malignancy of thyroid nodules in a group of Tunisian patients.Methods: We conducted a retrospective descriptive study including 100 patients collected in the endocrinology department of La Rabta hospital. All these patients underwent thyroidectomy...

Introduction: The main objective in the management of primary hypothyroidism is to normalize thyrotropin (TSH) level with Levothyroxine replacement therapy. The optimal dose of Levothyroxine may be affected by several factors such as age, gender, body weight, some medical disorders and drugs intake. The aim of this study was to assess the relationship between thyroid antibody titers and Levothyroxine dose in patients with primary hypothyroidism secondary to Hashimoto thyroidit...

Introduction: The goiter represents the most common of all the disorders of the thyroid gland. Many Factors may be involved in the evolution of multinodular goiter. Although thyroid stimulating hormone (TSH) was described as the most important goitrogen factor, impairment of TRH-induced TSH release was reported with nodular goiter, suggesting thyroid autonomy. Herein, we report two cases of an isolated thyrotropin deficiency in patient presented with a voluminous goiter.<p...

Abnormal movements like hemichorea are rarely described as neurological manifestations of hyperglycemia. It is occur in nonketotic hyperglycemia with a pathognomonic radiological findings. We report a case of a 70 years old women with no past medical history who presented to the emergency department with abnormal limb movements. It was repetitive, brief, involuntary movement of the right arm evolving for 5 days. On admission, neurological examination showed right hemichorea. S...

Introduction: Hypothyroidism is not a common cause of renal failure which remains under-appreciated. Herein we report a case of acute renal failure in a patient with a severe primary hypothyroidism in whom hormone replacement therapy with Levothyroxine has significantly improved renal function.Observation: A 72-year-old man was referred to our department for primary hypothyroidism. His past medical history included a coronary heart disease with a heart f...

The risk of hypotension during Ramadan fasting in patients with adrenal insufficiency is unknown. The aim of our study was to evaluate objectively this risk.Methods: It is a prospective case-crossover study on 28 patients with known and treated AI. Patients had no hypertension and were regular fasters. All patients underwent a clinical examination and a 24-hours blood pressure monitoring during Ramadan fasting then outside fasting....